Abstract

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Title:: Four-dimensional (spatio-temporal) consistency of local neural activity in type 2 diabetes patient on fMRI

Author(s):: LI Yuyao1; LI Jing1; JIAO Qing1; XUE Yazhuo2; LIU Xinfeng3; CAO Weifang1; GUO Yongxin1; CUI Dong1; LIU Ming3; 1. School of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai’an 271016, China; 2. School of Nursing, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai’an 271016, China; 3. Department of Endocrinology, Shandong Provincial Taishan Hospital, Tai’an 271000, China

Keywords:: ; Keywords: type 2 diabetes; functional magnetic resonance imaging; four-dimensional (spatio-temporal) consistency; plasma glucose

Abstract:: Abstract: Objective To investigate the abnormities in the brain function and plasma glucose level of type 2 diabetes (T2D) patients by functional magnetic resonance imaging (fMRI) and clinical data. Methods The fMRI signals of 34 T2D patients and 37 healthy controls were collected. The four-dimensional (spatio-temporal) consistency (FOCA) of local neural activities was calculated. The information of clinical laboratory examination of subjects was also collected, and the correlations between FOCA and clinical information were analyzed. Results Compared with that of healthy controls, the FOCA of T2D patients was significantly decreased in left middle temporal gyrus and right superior temporal gyrus, while increased in right cerebellum. The FOCA of left middle temporal gyrus was negatively correlated to fasting plasma glucose and postprandial blood glucose. Conclusion T2D patients have abnormal spontaneous neural activities in certain brain areas which includes right cerebellum, right superior temporal gyrus and left middle temporal gyrus, and the abnormal activity of left middle temporal gyrus is related to fasting blood glucose and two-hour postprandial plasma glucose in T2D patients.