Abstract

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Author(s):: SHAN Shucan; OU Dan; HAN Yimin; WANG Yujie; ZHOU Hui; CHEN Jiayi; Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China

Keywords:: ; Ruijin Hospital; Shanghai Jiaotong University School of Medicine; Shanghai 200025; China

Abstract:: Abstract: Objective To discuss the feasible of volumetric modulated arc therapy (VMAT) for the protection of the hippocampus in whole brain radiotherapy (WBRT), and investigate the advantages and disadvantages of coplanar and non-coplanar VMAT plans for hippocampal-sparing WBRT. Methods Ten patients receiving WBRT for brain metastases were enrolled in this study. Two different plans, namely coplanar and non-coplanar VMAT plans, were designed for each patient. The monitor unit, the homogeneity index and conformity index of target areas, and the organs-at-risk dose were compared between two plans. Results Both the two plans reduced the dose of the hippocampus, and the Dmean of the hippocampus in coplanar and non-coplanar VMAT plans were 9.7 and 9.6 Gy, respectively. Moreover, the mean values of the D100%, Dmean, D40%, and Dmax of the hippocampus were similar in the two plans, and no statistical difference was found in the homogeneity index and conformity index of target areas. However, the monitor unit of non-coplanar VMAT plan was larger than that of coplanar VMAT plan. The organs-at-risk doses in the two plans met the clinical requirements. Conclusion Both coplanar and non-coplanar VMAT plans for hippocampal-sparing WBRT satisfy the clinical requirements, and the difference between the two plans is trivial.