Dosimetric comparison of two kinds of radiation techniques of D2SRS and CyberKnife in stereotactic radiotherapy for brain metastases(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2020年第3期
- Page:
- 265-269
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Dosimetric comparison of two kinds of radiation techniques of D2SRS and CyberKnife in stereotactic radiotherapy for brain metastases
- Author(s):
- GE Ruigang; XIE Chuanbin; DAI Xiangkun; LI Jiwei; CHEN Gaoxiang; XU Shouping; QU Baolin
- Department of Radiation Oncology, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
- Keywords:
- Keywords: brain metastases; stereotactic radiotherapy; D2SRS; CyberKnife; dosimetry
- PACS:
- R318；R739.41
- DOI:
- DOI:10.3969/j.issn.1005-202X.2020.03.001
- Abstract:
- Abstract: Objective To analyze the dosimetric characteristics of two radiation techniques of D2SRS system on conventional accelerator in the radiotherapy for brain metastases, and to compare the two techniques with CyberKnife (CK) for exploring the feasibility of D2SRS in the stereotactic radiotherapy for brain metastases. Methods Thirty patients with brain metastases who were treated with CK were enrolled in the study, and two different D2SRS plans, namely DMLC-IMRT plan and DCA plan, were designed for each patient. The dosimetric characteristics of two D2SRS plans were analyzed and then compared with those of CK plan. Results All 3 kinds of plans met the prescription dose requirements. Among them, CK plan had the best conformity index (CI=0.82±0.04) and the highest homogeneity index (HI=0.42±0.11); the CI in DMLC-IMRT plan was similar to that in CK plan (0.80±0.07 vs 0.82±0.04, P=0.24), and the HI in DMLC-IMRT plan was lower than that in CK plan (0.28±0.13 vs 0.42±0.11, P=0.00); moreover, DCA plan had the lowest CI (0.69 ±0.09) and a HI (0.33±0.11) lower than CK plan. CK technique had more advantages in dose gradient outside the target areas, but there was no statistical significance compared with DCA plan (P=0.06). The delivery time of DMLC-IMRT plan and DCA plan was (16.94±1.50) min and (12.67±0.52) min, respectively, obviously shorter than (38.76±5.60) min in CK plan. Conclusion All 3 kinds of techniques meet the prescription dose requirements. CK plan has better performances in CI, while DCA plan is superior to DMLC-IMRT and close to CK plan in terms of dose gradient outside target area. Because of the significant advantages in delivery efficiency, two D2SRS plans can achieve an uniform irradiation in the radiotherapy for brain metastases more efficiently, having certain clinical application value.
Keywords: brain metastases; stereotactic radiotherapy; D2SRS; CyberKnife; dosimetry
Last Update: 2020-04-02