Application of apparent diffusion coefficient values of magnetic resonance diffusion-weighted imaging to evaluate the therapeutic effect of TACE in patients with liver cancer(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2019年第5期
- Page:
- 575-578
- Research Field:
- 医学影像物理
- Publishing date:
Info
- Title:
- Application of apparent diffusion coefficient values of magnetic resonance diffusion-weighted imaging to evaluate the therapeutic effect of TACE in patients with liver cancer
- Author(s):
- ZHANG Li1; PENG Zhiyi2
- 1. School of Meidicine, Zhejiang University, Hangzhou 310058, China; 2. The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
- Keywords:
- ; Keywords: liver cancer; apparent diffusion coefficient; magnetic resonance diffusion-weighted imaging; transhepatic arterial chemoembolization
- PACS:
- R445.2；R735.7
- DOI:
- DOI:10.3969/j.issn.1005-202X.2019.05.016
- Abstract:
- Abstract: Objective To analyze the value of apparent diffusion coefficient (ADC) values of magnetic resonance diffusion-weighted imaging (MR-DWI) in the evaluation of the therapeutic effect of transhepatic arterial chemoembolization (TACE) for liver cancer. Methods A total of 52 patients with hepatocellular carcinoma were enrolled in this study, with a total of 79 lesions and a total of 161 TACE treatments. MR-DWI was performed at different times (before treatment, after treatment, 1 month after treatment and 3 months after treatment). The ADC values ??of normal liver tissues and tumor tissues were measured before and after treatment. According to the efficacy evaluation criteria, the patients were classified into 3 groups, namely complete remission group, partial remission group and progression group. The changes of ADC values before and after treatment and during follow-up were analyzed. Results The ADC value of tumor lesions after treatment was (1.48±0.16)×10-3 mm2/s, significantly higher than (1.22±0.15)×10-3 mm2/s of normal liver tissues. After treatment, the increase of ADC value of the tumor tissue area was most obvious in complete remission group, followed by partial remission group and progression group. Statistical differences were found in the ADC value of tumor tissue area ??between complete remission group and partial remission group before and after treatment (P<0.05), while no statistical difference was found in the intra-group comparison (P>0.05). There were significant differences between any two groups at 1 month and 3 months after treatment (P<0.05), and the differences in the comparison among 3 groups has statistical significance (P<0.05). Conclusion The ADC value of magnetic resonance diffusion-weighted imaging provides a good reference value for the evaluation of chemotherapeutic efficacy of TACE in patients with liver cancer.
Last Update: 2019-05-23