Therapeutic efficacy of low-frequency repetitive transcranial magnetic stimulation in post-stroke depression: a Meta-analysis(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2019年第6期
- Page:
- 736-744
- Research Field:
- 医学生物物理
- Publishing date:
Info
- Title:
- Therapeutic efficacy of low-frequency repetitive transcranial magnetic stimulation in post-stroke depression: a Meta-analysis
- Author(s):
- CHEN Liang1; CHEN Jie2; JIN Ge1; HU Ling1; LI Xinggui1; ZHAN Qunling1
- 1. Department of Neurology, the Fifth People’s Hospital of Chongqing, Chongqing 400062, China; 2. Department of Medical Services, the Fifth People’s Hospital of Chongqing, Chongqing 400062, China
- Keywords:
- ; Keywords: low-frequency repetitive transcranial magnetic stimulation; post-stroke depression; Meta analysis
- PACS:
- R312；R743.3
- DOI:
- DOI:10.3969/j.issn.1005-202X.2019.06.023
- Abstract:
- Abstract: Objective To systematically assess the therapeutic efficacy of low-frequency repetitive transcranial magnetic stimulation (rTMS) in post-stroke depression (PSD). Methods The randomized controlled trials on low-frequency rTMS for post-stroke depression were retrieved from several databases, including Cochrane Library, Medline, Embase and China Biology Medicine disc (CBM), and the retrieve time range was from the establishment to October 2017. The relevant literatures from January 2005 to October 2017 were collected, and RevMan 5.1 software was used to perform Meta-analysis on the literatures included in the study. Results Among the relevant literatures from January 2005 to October 2017, a total of 21 randomized controlled trials which included 1 626 PSD patients met the criteria. The results of Meta-analysis showed that compared with those of antidepressant group, the Hamilton depression rating scale (HAMD) score of rTMS groups (0.5 Hz and 1 Hz) decreased more obviously ［0.5 Hz: ［SMD=-0.95, 95%CI (-1.19, -0.70), P<0.000 01］; 1 Hz: ［SMD=-0.44, 95%CI (-0.66, -0.23), P<0.000 1］］; and that the HAMD scores of rTMS groups (0.5 Hz and 1 Hz) were significantly lower than those of control group, with statistical significance ［0.5 Hz: ［SMD=-1.35, 95%CI(-1.70，-1.01), P<0.000 01］; 1 Hz: ［SMD=-1.03, 95%CI(-1.39, -0.67), P＜0.000 01］］. The barthel index and minimum mental state examination (MMSE) score in rTMS group were superior to those in control group ［Barthel index: ［SMD=1.38, 95%CI (0.87, 1.89), P<0.000 01］; MMSE: ［SMD=0.60, 95%CI (0.31, 0.90), P<0.000 1］］. There was no significant difference in national institute of health stroke scale (NIHSS) score between the two groups after treatment. In addition, the patients in rTMS group had adverse reactions, such as headache. Conclusion Low-frequency rTMS can significantly alleviate the depression of PSD patients, improve their daily living abilities, and enhance their cognitive functions. However, there is insufficient evidence for the improvement of NIHSS score with low-frequency rTMS. Moreover, PSD patient treated with low-frequency rTMS may have mild complications such as headache. Therefore, a high-quality clinical research validation is required.
Last Update: 2019-06-25