Abstract

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Title:: Application status of artificial lumbar disc replacement for lumbar degenerative disc disease

Author(s):: YANG Fengguang1; 2; 3; REN Enhui1; 2; 3; YANG Liang1; 2; 3; WANG Yonggang1; 2; 3; WANG Jing1; 2; 3; KANG Xuewen1; 2; 3; 1. Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou 730000, China; 2. Key Laboratory of Osteoarthritis of Gansu Province, Lanzhou 730000, China; 3. International Scientific and Technological Cooperation Base of Gansu Province for the Research on Pain Mechanism of Spinal Disorders, Lanzhou 730000, China

Keywords:: Keywords: lumbar degenerative disc disease; artificial lumbar disc replacement; biomechanical characteristic; review

Abstract:: Abstract: Artificial lumbar disc replacement (ALDR) is an innovative treatment of lumbar disc degeneration disease (LDDD) by replacing the intervertebral disc with artificial prosthesis, restoring the height of the intervertebral space while maintaining the stability of the spine and a certain range of motion, thereby reducing the incidence of adjacent segment disease. Herein the current clinical applications of artificial lumbar disc replacement in the treatment of LDDD are reviewed. Charité, ProDisc and Activ-L are commonly used artificial intervertebral discs in clinic. Due to the lack of obvious curative effect, the artificial intervertebral discs of Charité series have been gradually withdrawn from the market in 2012. For the artificial intervertebral discs of ProDisc series, ProDisc II and ProDisc-L are commonly used in clinic. ALDR which can effectively retain the range of motion of the replacement segment and reduce the incidence of adjacent segment disease has good short- and medium-term therapeutic effects on LDDD. However, the complications such as the subsidence, displacement and wear of prosthesis, heterotopic ossification and late replacement segment fusion can’t be ignored. Long-term clinical efficacy and potential complications of ALDR for LDDD still require long-term, large-sample follow-up studies.