Application of basis material decomposition technique with energy spectral CT in the quantitative study on blood flows in cirrhotic liver and healthy liver(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2019年第10期
- Page:
- 1200-1206
- Research Field:
- 医学影像物理
- Publishing date:
Info
- Title:
- Application of basis material decomposition technique with energy spectral CT in the quantitative study on blood flows in cirrhotic liver and healthy liver
- Author(s):
- REN Zhanli1; 2; LEI Yuxin1; CHEN Xiaoxia1; JIA Yongjun1; YU Nan1; YU Yong1; GUO Changyi2; HE Taiping1; ZHANG Xirong1
- 1. Department of Radiology, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, China; 2. CT Room, the Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, China
- Keywords:
- Keywords: energy spectral CT; material decomposition; liver cirrhosis; blood flow quantification
- PACS:
- R575.2
- DOI:
- DOI:10.3969/j.issn.1005-202X.2019.10.017
- Abstract:
- Abstract: Objective To evaluate the application value of basis material decomposition technique with energy spectral CT in the quantitative study of blood flows in Child-Pugh A cirrhotic liver and healthy liver. Methods Thirty patients who were diagnosed with Child-Pugh A liver cirrhosis and examined with upper-abdomen enhanced CT were enrolled as liver cirrhosis group, while 30 subjects without any abnormality in the enhanced CT examination of liver and portal vein were selected as healthy liver group. All patients underwent energy spectral CT imaging, and the images of 70 keV monochromatic energy and iodine-based material decomposition were reconstructed. The CT values and iodine concentrations of different liver lobes (caudate lobe, left lateral lobe, left inner lobe, right anterior lobe and right posterior lobe) were measured on 70 keV monochromatic energy and iodine-based material decomposition images in both arterial phase and portal venous phase. The arterial iodine fraction and portal venous iodine concentration (PVIC) of the liver were also calculated. These spectral parameters between two groups were compared with independent sample t test. Finally, receiver operating characteristic curve was used for analyzing the diagnostic performance of each spectral parameter. Results The CT values and iodine concentrations of liver cirrhosis group in the arterial phase were similar to those of healthy liver group (P>0.05), but the CT values and iodine concentrations of liver cirrhosis group in the portal venous phase were significantly lower than those of healthy liver group (P<0.05). Compared with healthy liver group, liver cirrhosis group had slightly higher arterial iodine fractions (P>0.05) and significantly lower PVIC (P<0.05). The average iodine concentration of liver in the portal venous phase which was 21.47 mg/mL was used as the threshold value to evaluate the blood flow between cirrhotic liver and healthy liver, the area under receiver operating characteristic curve was 0.790, with a sensitivity of 77.8% and a specificity of 83.3%, which was significantly higher than the diagnostic performance of CT values and PVIC. Conclusion The basis material decomposition technique with energy spectral CT can be used to assess the hemodynamic changes and differences between cirrhotic liver and healthy liver, providing more evidence for the early diagnosis of liver cirrhosis.
Last Update: 2019-10-30