Abstract

Info

Author(s):: CAO Tingting1; 2; DAI Zhitao2; LIWuzhou2; ZHANG Jun1; QUAN Hong2; LIU Hui1; CHEN Ji1; 1. Department of Radiation Oncology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China; 2. School of Physics and Technology,Wuhan University,Wuhan 430072, China

Keywords:: Keywords: radiobiological model; plan evaluation; tumor control rate; normal tissue complication; secondary cancer risk

Abstract:: Abstract: The radiotherapy plan evaluation which is mainly based on dose-volume histogram fails to reflect the biological effects of tumor and normal tissues after receiving dose. In recent years, biological model has been applied to radiotherapy plan evaluation for further reflecting its biological effects and clinical effects. Herein the development of different biological models such as cell survival model, tumor control probability model, normal tissue complication probability model and secondary cancer risk prediction model are briefly summarized. The linear-quadratic model of cell survival model is described, and other modified models are proposed for high dose, high dose rate and damage repair. For tumor control probability model and normal tissue complication probability model, different Poisson models and logical models based on Poisson function and logical relationship were introduced. For secondary cancer risk prediction model, the development of different prediction models based on linearquadratic model and the models considering cell proliferation are summarized briefly.