Abstract

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Title:: Neurobiological bases and electrophysiological manifestations of cognitive impairments in patients with schizophrenia

Author(s):: LI Jiahui1; 2; LIU Jianpeng3; PAN Zhilin1; 2; XIONG Dongsheng1; WU Fengchun2; 4; CHEN Jun5; 6; WU Kai1; 2; 5; 6; 1. Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou 510006, China; 2. Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou 510370, China; 3. Guangzhou Nanyang Polytechnic College, Guangzhou 510900, China; 4. Department of Clinical Psychology, the Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou 510370, China; 5. Guangdong Engineering Technology Research Center for Diagnosis and Rehabilitation of Dementia, Guangzhou 510500, China; 6. National Engineering Research Center for Healthcare Devices, Guangzhou 510500, China

Keywords:: Keywords: schizophrenia; cognitive impairment; neurotransmitter; electroencephalogram; review

Abstract:: Abstract: Patients with schizophrenia have severe cognitive impairments. The important neurobiological basis of cognitive impairments is the abnormal level of neurotransmitters in the brain, which will lead to abnormal electrical activity of neurons. Electroencephalograph can be used to reflect the abnormal electrical activities caused by neurotransmitters objectively and quantitatively. Herein the researches on the neurobiology and electrophysiology of cognitive impairments in patients with schizophrenia at home and abroad are reviewed; the biological mechanisms of neurotransmitters related to cognitive impairments are analyzed; and the related abnormal bioelectrical indicators are sorted out, thus providing relevant reference for the pathogenesis study and auxiliary diagnosis of schizophrenia. In the future, more attention should be paid to the pathogenic genes, neuroimaging and other biological markers of the disease, and the establishment of an indicator system for the auxiliary diagnosis of schizophrenia.