Abstract

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Title:: Progress in biophysical effects of low-intensity pulsed ultrasound and related mechanisms

Author(s):: GUO Shuang1; MAN Jiangwei1; JIANG Chunqian2; LI Xuanpeng1; WANG Huabin1; REN Xiaoshan1; HAN Yuanming1; WANG Cheng3; FU Shengjun1; YANG Li1; 1. Gansu Key Laboratory of Urinary System Disease Research/Gansu Clinical Medicine Center of Urinary System Disease/Department of Urinary Surgery, Lanzhou University Second Hospital/Institute of Urinary Surgery, Lanzhou University, Lanzhou 730030, China;
2. Department of Paediatrics, Lanzhou University Second Hospital, Lanzhou 730030, China; 3. Department of Pathology, West China Second University Hospital, Sichuan University, Chengdu 610041, China

Keywords:: Keywords: low-intensity pulsed ultrasound; cavitation; biophysical effect; biological mechanism

Abstract:: Abstract: As a non-invasive treatment approach, low-intensity pulsed ultrasound (LIPUS) which has low energy intensity (< 3 W/cm2) and outputs in pulse waves is gradually used in clinic. LIPUS has an insignificant thermal effect due to its low intensity pulse output mode, and the therapeutic effect of LIPUS mainly depends on its non-thermal effect. The corresponding molecular biological mechanisms of LIPUS mainly include related signal transduction pathways, gene expression, angiogenesis and stem cell differentiation. At present, the specific mechanism of LIPUS is very complex. Herein the biophysical effects and mechanisms of LIPUS are reviewed, so as to provide the corresponding theoretical basis and the latest research progress for the widespread application of LIPUS in more diseases.