Dosimetric study on coplanar and noncoplanar volumetric modulated arc therapy and helical tomotherapy for hepatocellular carcinoma(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2019年第8期
- Page:
- 877-881
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Dosimetric study on coplanar and noncoplanar volumetric modulated arc therapy and helical tomotherapy for hepatocellular carcinoma
- Author(s):
- YAN Bing; WU Aidong; ZHANG Hongbo; LIU Lei; XUE Xudong; SHEN Qi
- Department of Radiation Oncology, the First Affiliated Hospital of USTC (Anhui Provincial Hospital), Hefei 230001, China
- Keywords:
- ; Keywords: hepatocellular carcinoma; coplanar volumetric modulated arc therapy; noncoplanar volumetric modulated arc therapy; helical tomotherapy; dosimetry
- PACS:
- R735.7；R815
- DOI:
- DOI:10.3969/j.issn.1005-202X.2019.08.003
- Abstract:
- Abstract: Objective To compare the differences in normal liver tissue sparing and target dose distribution among coplanar volumetric modulated arc therapy (C-VMAT), noncoplanar VMAT (NC-VMAT), and helical tomotherapy (HT) for hepatocellular carcinoma. Methods Three plans, namely C-VMAT, NC-VMAT and HT plans, were designed for 10 patients with hepatocellular carcinoma. The dosimetric differences of target areas and organs-at-risk among different plans were evaluated with dose volume histogram. Results The maximum dose, mean dose, D2 and homogeneity index of target areas in HT plan were better than those in C-VMAT plan and NC-VMAT plan (P<0.05), while the minimum dose, D98 and conformity index of target areas were similar in 3 plans. Expect for the D98 of target areas, no statistical difference was found between C-VMAT plan and NC-VMAT plan (P?0.05). NC-VMAT plan had obvious advantages in the low-dose volume (V5 and V10) of normal liver tissues. However, HT plan was superior to C-VMAT plan and NC-VMAT plan in the high-dose volume (V40 and V50) of normal liver tissues. The maximum dose of spinal cord in NC-VMAT plan was the least, and there was significant difference in the maximum dose of spinal cord between C-VMAT plan and NC-VMAT plan. The mean doses of left and right kidneys in NC-VMAT plan were higher than those in C-VMAT plan, with significant differences (P<0.05), and no significance was found in the other dosimetirc parameters of normal tissues among 3 groups. Conclusion All of the 3 plans satisfy the requirement of prescribed dose. Compared with VMAT plans, HT plan increases the homogeneity index of target areas, and reduces the high-dose volume of normal liver tissues. However, the low-dose volume of normal liver tissues can be reduced in NC-VMAT plan.
Last Update: 2019-08-26