Correlation between energy spectrum CT quantitative parameters and bone biomechanics(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2018年第8期
- Page:
- 978-982
- Research Field:
- 生物材料与力学
- Publishing date:
Info
- Title:
- Correlation between energy spectrum CT quantitative parameters and bone biomechanics
- Author(s):
- DONG Qiang1; 2; XIE Qiqi1; 3; ZHAO Ruochen1; 4; HUANG Xiaoyu1; 5; LI Wenzhou1; 3; ZHANG Yinian1; 2; PAN Yawen1; 2; 6
- 1. Lanzhou University, Lanzhou 730000, China; 2. Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou 730000, China; 3. Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou 730000, China; 4. Department of Critical Care Medicine, Lanzhou University Second Hospital, Lanzhou 730000, China; 5. Department of Radiology, Lanzhou University Second Hospital, Lanzhou 730000, China; 6. Institute of Neurology, Lanzhou University, Lanzhou 730000, China
- Keywords:
- ; Keywords: energy spectrum CT; ash density; bone biomechanics; osteoporosis; correlation
- PACS:
- R312
- DOI:
- DOI:10.3969/j.issn.1005-202X.2018.08.021
- Abstract:
- Abstract: Objective To evaluate osteoporosis by the detection of energy spectrum CT quantitative parameters, and explore the correlation between energy spectrum CT quantitative parameters and bone biomechanics. Methods Twenty female Sprague-Dawley rats without special pathogen were selected and randomly divided into two groups, namely sham operation group (group A) and simple castration group (group B), with 10 rats in each group. The rats in group B were subjected to bilateral oophorectomy to establish an osteoporotic rat model and continued to be fed for 3 months. Dual-energy X-ray absorptiometry was used to measure the whole body bone mineral density (BMD) in order to determine whether the model was successfully established. After the in vivo BMD was measured with energy spectrum CT quantitative parameters, the rats were sacrificed and lumbar vertebra L4 was collected for further experiment and the attachment vertebral body was removed. After the lumbar compression test, the ash weight was measured. The correlation of BMD obtained by different energy spectrum CT quantitative parameters (hydroxyapatite-water-based material pair, calcium-water-based material pair, iron-water-based material pair and blood-water-based material pair) with ash density values and the biomechanical values obtained from the L4 compression test were analyzed. Results The correlation analysis between BMD obtained by different energy spectrum CT quantitative parameters and ash density values showed that hydroxyapatite-water-based material pairs and calcium-water-based material pairs had strong correlations with the ash density values, and that hydroxyapatite-water-based material pairs had the best correlation, but iron-water-based material pairs and blood-based material pairs had poor correlations. The correlation analysis between energy spectrum CT quantitative parameters and biomechanics also showed that the correlation of base material with elastic modulus and the maximum load was the best when using hydroxyapatite-water-based material pairs. Conclusion The BMD obtained by energy spectrum CT imaging are consistent with the change trends of ash density values and bone biomechanics. The hydroxyapatite-water-based material pairs of energy spectrum CT imaging has the best correlation with the ash density values, and the best correlation with bone biomechanics, which makes it the best quantitative parameter for bone strength evaluation.
Last Update: 2018-07-26