Abstract

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Title:: Effects of reversal potential on action potential based on Hodgkin-Huxley model

Author(s):: YI Feihong1; 2; LU Mai1; CHEN Kai1; 2; 1. Key Laboratory of Optoelectronic Technology and Intelligent Control (Ministry of Education), Lanzhou Jiaotong University, Lanzhou 730070, China; 2. School of Automation and Electrical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China

Keywords:: ; Keywords: neuron; ion channel; reversal potential; numerical simulation; Hodgkin-Huxley; action potential

Abstract:: Abstract: Objective To investigate the effects of different ion channel reversal potential parameters on action potentials in neurons using numerical simulation. Methods With the reference of physiological experiment results, Simulink software was used to established Hodgkin-Huxley models of 3 ion channels (Na channel, K channel, and leakage channel) with reversal potentials deviating from the standard value of ±10%, ±20% and ±30%. The same stimulation current was applied to obtain the response results of action potentials in neurons. Results The neurons were unable to generate continuous action potentials when the reversal potentials of 3 ion channels, namely ENa, EK and El, were too small. When increasing in a certain range, ENa, EK and El increased the number of action potentials in the same time period. When the changes of EK resulted in the abnormal discharge of neurons, the normal discharge could be restored by adjusting ENa. Conclusion The mutations of ion channel reversal potentials cause the abnormal discharge of neurons, which might be the reason of channelopathies. The simulation results show that the treatment of channelopathies can be carried out with the parameter adjustment of different ion channels at the same time, which provides some ideas and methods for the research of the pathogenesis and clinical treatment of channelopathies.