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Title:: Research status of Piezomechano-sensitive ion channels and their research progress in bone and joint tissues

Author(s):: YAN Liang1; 2; 3; JIANG Jin1; 2; 3; WAN Lang1; 2; 3; MA Chongwen1; 2; 3; YANG Xinxin1; 2; 3; XIA Yayi1; 2; 3; 1. Lanzhou University, Lanzhou 730000, China; 2. Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou 730000, China; 3. Key Laboratory of Osteoarthritis of Gansu Province, Lanzhou 730000, China

Keywords:: ; Piezo1; Piezo2; ion channel; nucleus pulposus cell; chondrocyte; osteosarcoma cell; osteoblast; review

Abstract:: Abstract: Mechano-sensitive ion channels are a type of ion channels closely related to biomechanical mechanical signal transmission. Once discovered, they attracted widespread attention from scholars at home and abroad. Recently, a new class of membrane channels which are almost ubiquitous has been identified in mammalians, namely Piezo1 and Piezo2, which are thought to play a crucial role in the mechanobiology of mammals. Bone cells, chondrocytes, nucleus pulposus cells, osteosarcoma cells and osteoblasts can sense mechanical and mechanical stimuli in the extracellular environment and activate signal transduction pathways through mechanically sensitive ion channels, thus affecting cell proliferation, differentiation, migration and apoptosis. Herein the research status of the Piezo-sensitive ion channel and its research in the bone and joint field are reviewed.