TBSS-based study of left-right asymmetry of white matter in young smokers(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2019年第1期
- Page:
- 65-70
- Research Field:
- 医学影像物理
- Publishing date:
Info
- Title:
- TBSS-based study of left-right asymmetry of white matter in young smokers
- Author(s):
- ZHANG Xiaohua; WANG Xianfu; CHEN Yajing; XIE Dongdong; LIU Chang; YU Dahua
- School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou 014010, China
- Keywords:
- Keywords: smoking addiction; white matter; left-right asymmetry; tract-based spatil statistics
- PACS:
- R318
- DOI:
- DOI:10.3969/j.issn.1005-202X.2019.01.013
- Abstract:
- Abstract: Objective To comprehensively analyze the left-right asymmetry of cerebral white matter structure in young smokers. Methods The diffusion tensor imaging data of cerebral white matter in 23 young smokers were processed and the brain regions with abnormal left-right asymmetries of white matter structure were analyzed with tract-based spatial statistics (TBSS) method. Results Obvious left-right asymmetries (FWE corrected P<0.05) of cerebral white matter were found in some brain regions in young smokers, including the body, genu and splenium of corpus callosum, anterior corona radiata, the anterior limb of internl capsule, etc. Pearson correlation analysis showed that the results of Fagerstrom test for nicotine dependence (FTND) were positively correlated with the axial diffusivity values of the body of corpus callosum, the genu of corpus callosum, anterior corona radiata (r=0.431, 0.429, 0.477; P=0.040, 0.041, 0.021), and negatively correlated with the axial diffusivity value of splenium of corpus callosum (r=-0.450, P=0.031). Moreover, there were significant positive correlations between the fractional anisotropy value of the genu of corpus callosum and FTND results (r=0.678, P=0.000376), and between the axial diffusivity value of anterior corona radiata and smoking index (pack-year) (r=0.493, P=0.017). Conclusion The abnormal left-right asymmetry exists in the white matter of some brain regions (such as corpus callosum and anterior corona radiate) in young smokers.
Last Update: 2019-01-24