Effects of nanosecond pulsed electric fields combined with anti-tumor drugs on the cell viability of human melanoma cell line A375(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2018年第6期
- Page:
- 714-719
- Research Field:
- 医学生物物理
- Publishing date:
Info
- Title:
- Effects of nanosecond pulsed electric fields combined with anti-tumor drugs on the cell viability of human melanoma cell line A375
- Author(s):
- QIAN Zeyi1; KUANG Dongdong2; LUO Qing2; SONG Guanbin2
- 1. Liangjiang Yucai Middle School, Chongqing 410020, China; 2. College of Bioengineering, Chongqing University, Chongqing 400030, China
- Keywords:
- ; nanosecond pulsed electric fields; human melanoma cell; anti-tumor drugs; synergistic effect; cell viability
- PACS:
- R312
- DOI:
- DOI:10.3969/j.issn.1005-202X.2018.06.017
- Abstract:
- Abstract: Nanosecond pulsed electric fields (nsPEFs) are promising in the treatment for cancer in clinic. Our previous study proved that nsPEFs can inhibit the cell viability and migration of human melanoma cell line A375. However, whether there is a synergy between nsPEFs and anti-tumor drugs remains unknown. Herein CCK-8 assay is used to investigate the synergistic effect of nsPEFs and anti-tumor drugs, dacarbazine and cisplatin, on the cell viability of A375 cells. The results show that nsPEFs combined with dacarbazine has a trivial synergistic effect, while nsPEFs combined with cisplatin has significant synergistic effect which is positively correlated with the input power of nsPEFs. This study provides research data for the application of nsPEFs combined with anti-tumor drugs in clinic.
Last Update: 2018-06-22