Abstract

Info

Title:: Linear regression analysis of drug release rule in electret 5-fluorouracil patch

Author(s):: LIANG Hejuan1; HUANG Ping1; LIANG Yuanyuan1; GUO Xin1; CUI Lili2; JIANG Jian1; 1. Department of Physics and Mathematics, Faculty of Health Service, the Second Military Medical University, Shanghai 200433, China; 2. Department of Inorganic Chemistry, School of Pharmacy, the Second Military Medical University, Shanghai 200433, China

Keywords:: ; Keywords: electret; 5-fluorouracil; drug release rule; linear regression analysis

Abstract:: Abstract: Objective To study the drug release rule in electret 5-fluorouracil (5-Fu) patch by linear regression method. Methods The electret 5-Fu patch was prepared by electret technology and pharmaceutical method, and the cumulative drug release from 5-Fu patch were detected by high-performance liquid chromatography. Regression analysis was performed on the test data to make it possible that the drug release rule in electret 5-Fu patch be modeled. Results Electret provided stable electrostatic field for 5-Fu patch, and the size of electrostatic field had positive correlations with the equivalent surface potentials of electret. The electrostatic field of electret 5-Fu patch effectively reduced the adhesion of patch, thus realizing the regulation of 5-Fu drug release. The smaller the adhesion of patch was, the higher the cumulative drug release (Q) from patch was. The drug release rule of electret 5-Fu patch accorded with the followed regression equations: V>0, Q=(0.003V+13.47)t1/2+0.136 6V1/2+47.574; V=0, Q=13.767t1/2+48.052; V<0, Q=(-0.003 8V+13.471) t1/2+0.162 2(-V)1/2+48.442. Conclusion The electrostatic field of electret can regulate the release velocity of drug from 5-Fu patch and the polarity and equivalent surface potential of electret are the key influence factors for the regulation.