Application of heparin in surface modification of small-caliber artificial blood vessels(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2018年第10期
- Page:
- 1236-1240
- Research Field:
- 医学生物物理
- Publishing date:
Info
- Title:
- Application of heparin in surface modification of small-caliber artificial blood vessels
- Author(s):
- JIA Shanshan; CHEN Qunqing; YAN Yusheng
- Zhujiang Hospital, Southern Medical University, Gunagzhou 510280, China
- Keywords:
- ; Keywords: artificial blood vessel; heparin; surface modification; hemocompatibility; review
- PACS:
- R318.08
- DOI:
- DOI:10.3969/j.issn.1005-202X.2018.10.025
- Abstract:
- Abstract: Small-caliber artificial blood vessels are not widely used in clinic because of its poor biocompatibility. Heparinized modification is the most effective method to improve the thrombogenesis-resistant for blood-contact materials. Herein the structure and properties of heparin are introduced. Three main methods used in surface modification of artificial blood vessels with heparin, namely covalent bonding, ion binding and sustained release, are briefly described. The advantages and limitations of various methods are summarized and the future development of heparin in the modification for artificial blood vessels is prospected.
Last Update: 2018-10-23