Effect of bone marrow-sparing intensity-modulated radiotherapy on acute myelosuppression in patients with cervical cancer(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2018年第4期
- Page:
- 399-403
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Effect of bone marrow-sparing intensity-modulated radiotherapy on acute myelosuppression in patients with cervical cancer
- Author(s):
- WEN Liedong; HUANG Wei; WU Wanchun; CUI Haixia; LU Wenli; LI Ying
- Department of Oncology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
- Keywords:
- ; cervical cancer; bone marrow-sparing intensity-modulated radiotherapy; acute myelosuppression; conformity index; homogeneity index
- PACS:
- R730.55; R737.33
- DOI:
- DOI:10.3969/j.issn.1005-202X.2018.04.006
- Abstract:
- Objective To investigate the effect of bone marrow-sparing intensity-modulated radiotherapy (BMS-IMRT) on acute myelosuppression in cervical cancer patients. Methods A total of 138 patients with cervical cancer undergoing concurrent chemoradiotherapy in the First Affiliated Hospital of Chongqing Medical University were divided into BMS-IMRT group (n=61) and IMRT group (n=77). During radiotherapy plan design, the pelvis dose was limited for patients in BMS-IMRT group, pelvis V10≤90%, V20≤70%, while the pelvis of patients in IMRT group was not given a limited dose. The differences in radiation toxicity on organs-at-risk between the two groups were compared. Results The dosimetric analysis revealed that the V5-V50 and Dmean of pelvis in BMS-IMRT group were significantly lower than those in IMRT group (P<0.05). No significant differences between the two groups were found in the dose-volume histogram parameters of organs-at-risk (the V5-V50 and Dmean of rectum and bladder) and the uniformity and conformity of target areas (P>0.05). The clinical observation of radiation toxicity and side effects showed that the incidence of acute myelosuppression of grade 2 and above in BMS-IMRT group was significantly lower than that in IMRT group, with statistically significant differences (P=0.029). The incidence of acute proctitis and cystitis of grade 2 and above between the two groups didn’t showed any differences (P=0.788, 0.503). Conclusion Compared with IMRT, BMS-IMRT can significantly reduce the incidence of acute myelosuppression of grade 2 and above in patients with cervical cancer, without affecting the target area dose and increasing the acute toxicity on bladder and rectum.
Last Update: 2018-04-23