Analysis of factors predicting radiation pneumonitis in volumetric modulated arc therapy of lung cancer(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2018年第7期
- Page:
- 771-775
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Analysis of factors predicting radiation pneumonitis in volumetric modulated arc therapy of lung cancer
- Author(s):
- ZHANG Yanqiu1; HAN Ameng2; LI Jinwang1; GU Tao1; FU Zhanzhao1; MAO Yu1; ZHANG Zijian3; YANG Zhen3
- 1. Department of Radiation Therapy, First Hospital of Qinhuangdao, Qinhuangdao 066000, China; 2. Information Technology Center, Yanshan University, Qinhuangdao 066004, China; 3. Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China
- Keywords:
- ; Keywords: volumetric modulated arc therapy; lung cancer; radiation pneumonitis; clinical factors; physical factors
- PACS:
- R818.8
- DOI:
- DOI:10.3969/j.issn.1005-202X.2018.07.006
- Abstract:
- Abstract: Objective To analyze the clinical factors and physical factors of patients receiving volumetric modulated arc therapy (VMAT) for lung cancer, and evaluate the correlation of clinical factors and physical factors with the incidence of radiation pneumonitis (RP). Methods The information of 40 patients receiving the first VMAT for lung cancer in the First Hospital of Qinhuangdao between July 2014 and October 2016 were retrospectively analyzed. The clinical data and physical factors were compared between patients developing RP and those without developing RP. The RP was defined by the imaging examination and RTOG standard after over 10-month follow-up studies. The correlations of clinical factors and physical factors with the incidence of RP of grade 2 or above were analyzed. Results Ten patients developed RP of grade 2 or above. The results of univariate analysis revealed that the clinical factors, including gender, age, pathological type, clinical stage, diabetes mellitus, surgery, tumor location, smoking, chemotherapy and obstructive pneumonia before radiotherapy, didn’t have any significant correlations with the incidence of RP (P>0.05). Among the physical factors of V5, V10, V13, V15, V20, V25, V30, V35, V40, Dmean, Dp and planning target volume, only V5, V10, V13, V15 had statistical correlations with the incidence of RP (P=0.018, 0.023, 0.012, 0.004) and no statistical correlations were found between the other factors and the incidence of RP (P>0.05). The results of multivariate analysis indicated that of all clinical and physical factors, only V5 was the risk factor of RP (P=0.003, OR=29.571). Conclusion The incidence of RP is significantly correlated with V5 in lung cancer patients treated with VMAT. When patients with lung cancer treated with ARC, the volume of low-dose irradiation (V5, V10, V13 and V15) should be strictly restricted, especially V5, in order to minimize the incidence of RP.
Last Update: 2018-07-24