Correlation between alpha-thalassemia genotypes and red blood cell parameters in Huizhou area(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2018年第5期
- Page:
- 608-611
- Research Field:
- 医学生物物理
- Publishing date:
Info
- Title:
- Correlation between alpha-thalassemia genotypes and red blood cell parameters in Huizhou area
- Author(s):
- HE Jihong; MA Lingdi; ZHANG Fangdi; WANG Jian; HE Xiaoqing
- The Third People’s Hospital of Huizhou City, Huizhou 516001, China
- Keywords:
- Keywords: alpha-thalassemia; genotype; red blood cell parameter
- PACS:
- R556.5
- DOI:
- DOI:10.3969/j.issn.1005-202X.2018.05.020
- Abstract:
- Abstract: Objective To study the changes of genotypes and red blood cell (RBC) parameters in patients with alpha-thalassemia in Huizhou area, and to provide preliminary evidence for the prediction of clinical alpha-thalassemia genotype. Methods Ninety patients with confirmed alpha-thalassemia genotypes were randomly divided into 3 groups, including 30 of silent alpha-thalassemias carriers, 28 diagnosed with standard alpha-thalassemia and 32 alpha-thalassemia patients with HbH. Meanwhile, 30 healthy controls were selected as control group. The RBC parameters were detected in each group, including RBC counting, hemoglobin (HGB), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and RBC distribution width (RDW). Results Alpha-thalassemia patients with different genotypes showed various degrees of hypochromic microcytic anemia symptoms. The levels of HGB, MCV and MCH in alpha-thalassemia patients of 3 genotypes were significantly lower than those in the control group and were negatively correlated to the degree of anemia, with statistical significance (P<0.05). Compared with normal controls, the patients of 3 genotypes had significantly higher RDW values which were positively correlated to the degree of anemia, with statistical differences (P<0.05). Alpha-thalassemia patients also showed significant differences in the corresponding RBC parameters when changing from silent gene type to HbH type (P<0.05). Conclusion RBC-related parameters have the potential to be predictors of alpha-thalassemia gene types, worthy of further large sample and multicenter studies.
Last Update: 2018-05-22