Abstract

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Title:: Application of morphological parameters analysis of ophthalmic microvasculature based on slit lamp in the diagnosis of ophthalmic diseases

Author(s):: WANG Gengyuan; LAI Guanquan; DUAN Zhengyu; LUO Zhongzhou; HUANG Yuancong; LIN Weifeng; Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China

Keywords:: ; : functional slit lamp biomicroscope; ophthalmic microvasculature; conjunctiva; fractal dimension; image processing

Abstract:: Objective To develop the analysis system of ophthalmic microvasculature and explore its application in conjunctival ophthalmopathy. Methods A friendly clinical multifunctional ophthalmic microvascular imaging platform was developed by integrating digital image acquisition device including high-speed camera and video capture card into standard slit lamp on the platform. The image analysis software was used for analyzing the images and image fractal difference, and quantitatively classifying vascular morphology including vascular morphology, density and complexity. Results The whole system was fully functional and stable. A model for the rapid analysis of blood flow parameters and morphological parameters of blood vessels was established, and the correlation between the pathogenic factors and microvascular functions was analyzed. Conclusion The fractal, morphological, and human conjunctival hemodynamics of the vascular network can be easily and reliably measured using functional slit lamp biomicroscope. The differences in fractal dimension may reflect certain diseases. Measuring and analyzing non-contact detection indicators, and discussing the specificity and sensitivity of detection indicators are of great importance in the ophthalmic diagnosis of microvascular function-related diseases and systemic diseases.