Abstract

Info

Author(s):: WANG Jun; SUI Li; CAI Ainan; WU Yongliang; School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China

Keywords:: ; cranial nerve; ultrasonic stimulation parameter; neuromodulation; review

Abstract:: In recent years, ultrasonic neuromodulation, as a new non-invasive technique to stimulate the brain, has received more and more attentions. In order to be able to use this technique more accurately for clinical application, scientists have done a lot of in vitro and in vivo animal studies. The results of these related studies showed that ultrasonic intensity, frequency, duration, pulse repetition frequency and the regional size of the irradiated target were the factors affecting the ultrasound stimulation effect, which indicated that we can adjust these ultrasonic stimulation parameters to make the central nervous system of the stimulated site produce excitatory or inhibitory effect, achieving reversible neuromodulation. In order to further reveal the relationship between the ultrasonic stimulation parameters and the effect of ultrasonic neuromodulation, herein we briefly describe the developmental process of ultrasound neuromodulation and its possible neural mechanisms, and focus on summarizing the effects of ultrasonic stimulation parameters on neuromodulation, and make preliminary prospect of future research on ultrasonic neuromodulation.