Abstract

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Title:: Gray matter density alteration and its correlation with cognitive impairment in patients with type 2 diabetes mellitus

Author(s):: WEI Tonghui1; LIU Xinfeng2; CUI Dong1; XUE Yazhuo3; GUO Yancheng3; LU Aixia3; CAO Weifang1; GUO Yongxin1; JIAO Qing1; 1. School of Radiology, Taishan Medical University, Tai’an 271016, China; 2. Taishan Sanatorium of Shandong Province, Tai’an 271000, China; 3. School of Nursing, Taishan Medical University, Tai’an 271016, China

Keywords:: ; type 2 diabetes mellitus; voxel-based morphology; gray matter density; cognitive impairment

Abstract:: Objectives To investigate the alteration of gray matter density (GMD) and its correlation with clinical indexes and cognitive impairment in patients with type 2 diabetes mellitus (T2DM) by the analysis method combining magnetic resonance imaging with voxel-based morphology. Methods The magnetic resonance images of 31 patients with T2DM and 32 healthy controls were collected, and GMD was calculated. After the GMD of brain regions showing significant differences were extracted, we analyzed the correlation between extracted GMD with clinical indexes and cognitive test results. Results Voxel-based morphology analysis results showed that GMD in the right cerebellum, the left middle temporal gyrus, and the left middle occipital gyrus was significantly reduced in T2DM patients compared to healthy controls (P<0.001). GMD in the right cerebellum and the left middle temporal gyrus was positively correlated with scores of mini-mental state examination. Conclusion T2DM patients develop structural atrophy in the cerebellum, the temporal lobe and the occipital lobe, and the GMD of these brain regions is related to the cognitive impairment in T2DM patients.