Abstract

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Title:: Radiosensitizing effect of FePt nanoparticle cluster under X-ray irradiation researched with Monte Carlo simulation

Author(s):: QI Pengyuan; MIU Hongtao; QUAN Hong; School of Physics and Technology, Wuhan University, Wuhan 430072, China

Keywords:: ; FePt; nanoparticles; Monte Carlo; Geant4; cluster; radiosensitizing effect; dose enhancement ratio

Abstract:: Objective To investigate the radiosensitizing effect of FePt nanoparticle cluster under X-ray irradiation with the use of Monte Carlo program Geant4 and compare the effects of cluster size, source energy and nanoparticle materials on the radiosensitizing effect. Methods Single nanoparticle cluster model and cell with nanoparticle cluster model were designed according to the images of cells processed with FePt nanoparticles. The dose enhancement ratio (DER) was used to evaluate the radiosensatizing effect and the DER of different models was calculated. Results The radiosensitizing effect of Fe1Pt3 nanoparticle cluster was superior to that of Fe1Pt1 nanoparticle cluster. Meanwhile, for the same nanoparticle cluster, the radiosensitizing effect was better under the irradiation of X-ray with lower energy. With the increasing thickness of nanoparticle cluster, DER gradually reached a saturated value. Conclusion The FePt nanoparticle cluster has desirable radiosensitizing effect, which verifies the clinical application of FePt nanomedicine.