Irradiation method of experimental cell on linear accelerator and dosimetry study(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2017年第12期
- Page:
- 1211-1215
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Irradiation method of experimental cell on linear accelerator and dosimetry study
- Author(s):
- LI Jianfeng1; HUANG Shunping2
- 1. Chongqing University Cancer Hospital/Chongqing Cancer Institute/Chongqing Cancer Hospital, Chongqing 400030, China; 2. the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
- Keywords:
- ; Keywords: linear accelerator; cell irradiation; side scattering; dosimetry
- PACS:
- R811.5
- DOI:
- DOI:10.3969/j.issn.1005-202X.2017.12.005
- Abstract:
- Abstract: Objective To explore the effect of culture medium of different depths, irradiation methods and cavity effect on the irradiation of experimental cell, and to minimize the uncertainty of exposure dose by providing reference for choosing the optimal irradiation method. Methods The culture medium of different depths was added into different culture dishes, with 1 cm of compensation on the cover and 4 cm of solid water on the bottom, and then, the irradiation at a gantry angle of 0° without side scattering was carried out for investigating the effect of the culture medium of different depths on the cell irradiation and obtaining the CT image. After the culture dish was placed into a larger culture dish with the same depth of culture medium to simulate the side scattering and the compensation and solid water were added as in previous treatment, the effect of the irradiation at a gantry angle of 0° with side scattering on cell irradiation was discussed and the CT image was obtained. The effect of the irradiation at a gantry angle of 180° with side scattering on cell irradiation was analyzed and CT image was obtained by replacing the previous compensation and solid water with 4 cm of solid water on the cover and 1 cm of organic vitreous membrane on the bottom. After removing the peripheral culture medium, we analyzed the effect of the irradiation a gantry angle of 180° without side scattering on cell irradiation. Based on those obtained CT images, treatment plans were designed and the dose distributions which were expressed in relative doses (%) were compared. Results The maximum dose deviation was 5.5%, 4.2%, and 6.5% for 2.5, 5.0, and 7.2 mm of culture medium, respectively. The maximum dose deviation and mean dose were 14.7% and 96.6% for the irradiation at a gantry angle of 0°without side scattering, and 4.9% and 97.1% for that with side scattering. Furthermore, the maximum dose deviation and mean dose were 10.5% and 98.6% for the irradiation at a gantry angle of 180° without side scattering, and 3.1% and 99.1% for that with side scattering. Conclusion For experimental cell irradiation, irradiation at a gantry angle of 180° has a smaller dose deviation and a better homogeneity than the irradiation a gantry angle of 0°, and adding side scattering can dramatically improve the dose distribution of lateral culture medium and adherent culture.
Last Update: 2017-12-20