Abstract

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Title:: Characteristics of intracerebral neurotransmitter activity on encephalofluctuograph in epileptic patients with anxiety and depression

Author(s):: LI Chun; HUANG Bo; TANG Haining; WEI Chaoyang; PAN Runde; LIANG Zhongwei; Department of Neurology, Guangxi Zhuang Autonomous Region Brain Hospital, Liuzhou 545005, China

Keywords:: ; epilepsy; anxiety and depression; intracerebral neurotransmitter; encephalofluctuograph

Abstract:: Objective To explore and analyze the encephalofluctuograph (EFG) features of intracerebral neurotransmitter activity in epileptic patients with anxiety and depression. Methods Thirty epileptic patients with anxiety and depression treated in Guangxi Zhuang Autonomous Region Brain Hospital from January 2014 to December 2015 were regarded as observation group, while 30 epileptic patients without anxiety and depression treated in the same hospital over the same period were regarded as control group. The EFG analyzer was used to detect the changes in intracerebral neurotransmitter activity and brain functional states in the two groups. Results No significant differences were found in intracerebral neurotransmitters between the two groups (P>0.05), except 5-HT which was significantly lower in observation group compared to control group. The exercise index, excitability and depression index, and vasomotor index in observation group were higher than those in control group, with significant differences (P<0.05). Conclusion The EFG characteristics in epileptic patients with anxiety and depression include abnormal intracerebral neurotransmitter activity and abnormal brain functional states, and these abnormalities are helpful in the differential diagnosis of epilepsy with anxiety and depression.