Causes of GFR calculation in unilateral kidney with Gates method being affected by different definition methods of ROI in contralateral kidney and an improved Gates algorithm(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2017年第12期
- Page:
- 1280-1286
- Research Field:
- 医学生物物理
- Publishing date:
Info
- Title:
- Causes of GFR calculation in unilateral kidney with Gates method being affected by different definition methods of ROI in contralateral kidney and an improved Gates algorithm
- Author(s):
- WANG Changyin1; ZHAO Yanfen2; SHEN Meijuan1; WEN Bing1; SHEN Ying1
- 1. Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; 2. Department of Applied Mathematics, School of Mathematics and Statistics, Wuhan University, Wuhan 430072, China
- Keywords:
- ; kidney; radionuclide imaging; glomerular filtration rate; region of interest; technetium 99m-diethylene triamine pentacetate acid; algorithm
- PACS:
- R817.47
- DOI:
- DOI:10.3969/j.issn.1005-202X.2017.12.017
- Abstract:
- Objective To analyze the reasons why the calculation of glomerular filtration rate (GFR) in unilateral kidney using Gates method is affected by different methods for defining contralateral kidney’s region of interest (ROI), and to explore an improved Gates algorithm. Methods The imaging data of 125 patients receiving renal dynamic imaging and GFR measurement were retrospectively reprocessed and analyzed. An improved split renal GFR algorithm was proposed, and the correction and difference between the improved algorithm and Gates algorithm were analyzed. Results The split renal GFR measured with the improved algorithm and that measured with Gates algorithm showed a strongly positive correlation (r=0.999, P=0.000), and the total renal GFR was unvaried in the two algorithms. The split renal GFR of Gates algorithm had an obviously positive correlation with renal uptake rate (r=0.999, P=0.000), but the one-to-one relationship was not found between them. A completely positive correlation (r=1.000, P=0.000) and a one-to-one relationship were found between the split renal GFR of the improved algorithm and renal uptake rate. The total renal GFR of both algorithms also had a completely positive correlation with renal uptake rate (r=1.000, P=0.000). With the decreasing size of ROI in contralateral kidney, the GFR in unilateral kidney measured with Gates algorithm gradually decreased, but that measure with the improved algorithm did not alter. Conclusion The improved split renal GFR algorithm ensures that the total renal GFR of both kidneys will not be affected by the size of ROI and avoids the shortcoming of Gates algorithm (the interaction between split renal GFR), ensuring the repeatability and reliability of split renal GFR measurement.
Last Update: 2017-12-21