Effects of oxygen-enriched atmospheres provided by portable oxygen-enriched machine on the behaviors of rats in a simulated chronic hypoxic environment(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2017年第11期
- Page:
- 1156-1159
- Research Field:
- 医学信号处理与医学仪器
- Publishing date:
Info
- Title:
- Effects of oxygen-enriched atmospheres provided by portable oxygen-enriched machine on the behaviors of rats in a simulated chronic hypoxic environment
- Author(s):
- DONG Xu1; 2; LEI Tao1; SHEN Guanghao1; XIE Kangning1; JING Da1; LIU Juan1; ZHAI Mingming1; LUO Erping1
- 1. School of Biomedical Engineering, the Fourth Military Medical University, Xi’an 710032, China; 2. Section of Research and Training, Department of Medical Affairs, Qingdao First Sanatorium, People’s Liberation Army Navy, Qingdao 266071, China
- Keywords:
- ; Keywords: portable oxygen-enriched machine; high altitude; hypoxic; oxygen enrichment; behavior
- PACS:
- R318
- DOI:
- DOI:10.3969/j.issn.1005-202X.2017.11.014
- Abstract:
- Abstract: Objective To simulate a chronic hypoxic environment, and then explore the effects of oxygen-enriched atmospheres provided by portable oxygen-enriched machine on the behaviors of rats in such environment. Methods Chronic hypoxic environment at a 5 000 m high altitude was simulated with small hypobaric chamber, and oxygen-enriched rooms were established by portable oxygen-enriched machines and individually ventilated cages. Thirty-six male Sprague-Dawley rats were randomly divided into 3 groups, including normal control group (NC group), high altitude hypoxia group (HH group) and high altitude oxygen enrichment group (HO group). Rats in HH group and HO group were fed in the small hypobaric chamber for 4 weeks (22 h/d), and rats in HO group were stay in oxygen-enriched rooms for 8 h every day. Rats in NC group were fed outside of the chamber. Bodyweight of rats were measured before treatment and at every week after the treatment. The behavior indices and mean values of skin blood flux were measured after the treatment. Results No statistical differences were found in the bodyweight of rats in 3 groups before treatment (P>0.05). After the treatment, the bodyweight of rats in HH group and HO group were significantly lower than that of rats in NC group (P<0.01), and no statistical difference was found between HH group and HO group (P>0.05). The comparison of the horizontal activity of the rats among 3 groups didn’t showed any statistical differences (P>0.05). Compared with that in NC group and HH group, the vertical activity of the rats in HO group was significantly increased (P<0.05, P<0.01), and no statistical difference was found between NC group and HH group (P>0.05). The rats in HH group had a significantly higher mean value of skin blood flux, as compared with the rats in NC group and HO group (P<0.01), and no statistical difference was found between NC group and HO group (P>0.05). Conclusion In a simulated chronic hypoxic environment at a 5 000 m high altitude, portable oxygen-enriched machine not only enhances the adaptive ability of rats by reducing the values of blood flux and the functional reserve of blood system, but also improves the brain function of rats such as cognitive ability and space exploration ability.
Last Update: 2017-11-23